However, this only applies to the adult patient population. For instance, a reference range for resting heart rate is between 60 and 100 beats per minute. When interpreting quantitative clinical measurements using reference ranges (developed using variance), it is of utmost importance to use the correct reference range.
Two concerns when considering variance in clinical and research contexts are: (1) using an appropriate reference population (2) ensuring statistical assumptions are met when using variance to develop statistical results.